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KMID : 0381120200420010001
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Genes and Genomics
2020 Volume.42 No. 1 p.1 ~ p.12
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Genome-wide identification and characterization of the AMPK genes and their distinct expression patterns in response to air exposure in the Manila clam (Ruditapes philippinarum)
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Wang Jingtian
Fang Lei
Wu Qidi
Li Dongdong
Huo Zhongming
Yan Xiwu
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Abstract
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AMP-activated protein kinases (AMPK) are heterotrimeric complexes. The main upstream phosphorylase has AMP-dependent LKB1 and Ca2+-dependent CaMKK beta. AMPK also includes an auto-inhibitory domain and a region associated with beta and gamma subunits, which regulate a variety of cellular activities and energy metabolism. The increase in the ratio of AMP/ATP can stimulate the activation of AMPK. Once AMPK is activated, pathways to ATP consumption (e.g., fat, cholesterol, and protein synthesis) will be shut down. The pathway to ATP generation (e.g., oxidation of fat and glycolysis pathway) will be activated. AMPK genes have not been systematically characterized in marine invertebrates.
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KEYWORD
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AMPK genes, Air exposure, Ruditapes philippinarum
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Listed journal information
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